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All Things Considered

Melissa Block and Robert Siegel

In-depth reporting and transformed the way listeners understand current events and view the world. Every weekday, hear two hours of breaking news mixed with compelling analysis, insightful commentaries, interviews, and special - sometimes quirky - features.Melissa Block and Robert Siegel

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Shots - Health News
2:04 pm
Wed January 2, 2013

Drug Fulfills Promise Of Research Into Cystic Fibrosis Gene

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Credit Vertex Pharmaceuticals Inc.
Kalydeco is one of the first drugs that is effective at combating the root causes of a genetic disease.
Credit Jeffrey Sauger
Emily Schaller suffers from cystic fibrosis. New treatments that target the genetic basis of her disease allow her to live an active, healthy life.
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Originally published on Wed January 2, 2013 6:53 pm

The promise of genetic medicine is beginning to be fulfilled, but it's been a long, hard slog.

Take the story of Kalydeco. It's designed to treat people with a lung disease called cystic fibrosis. While not quite a cure, the drug is extremely effective for some CF patients.

But the success of Kalydeco has been more than two decades in the making.

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Asia
10:01 am
Wed January 2, 2013

The Tony Soprano of Karachi: Gangster Or Politician?

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Credit Dina Temple-Raston
Baloch has been the most powerful figure in Karachi's Lyari neighborhood since 2009. His armed men control the area, and police stay away. He's shown here at his home.
Credit Dina Temple-Raston
Uzair Baloch is known as the don of Karachi's Lyari Town slum. He is pictured here at his home.
Credit Akhtar Soomro / Reuters/Landov
Uzair Baloch (center), 32, controls an impoverished section of Karachi and commands a large armed force. He is routinely described as a gangster, though he calls himself a politician and a social worker. He's shown here at a rally in Karachi in November 2011.
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Originally published on Wed January 2, 2013 6:56 pm

Gangsters have been part of life in Karachi, Pakistan's largest city, for decades. And nowhere is their rule more notorious than in the slums of Lyari, a dusty warren of low-slung tenement houses in the south central part of Karachi.

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Shots - Health News
5:21 pm
Tue January 1, 2013

What The Health Law Will Bring In 2013

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The majority of what happens on Jan. 1, 2013, is tax increases and cuts in tax deductions to pay for the changes coming in 2014.
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Originally published on Tue January 8, 2013 1:19 pm

Most of the really big changes made by the 2010 health law don't start for another year. That includes things like a ban on restricting pre-existing conditions, and required insurance coverage for most Americans. But Jan. 1, 2013, will nevertheless mark some major changes.

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Around the Nation
3:55 pm
Tue January 1, 2013

2013's New Laws Govern Driverless Cars, Employee Passwords

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Originally published on Tue January 8, 2013 1:19 pm

Transcript

AUDIE CORNISH, HOST:

From NPR News, this is ALL THINGS CONSIDERED. I'm Audie Cornish. New laws go into effect across the country today and we're going to look at a few of them that all struggle with the same problem, how to keep up with technology. We're going to hear about three of them now from Jon Kuhl of the National Conference of State Legislatures. The first deals with that perplexing new phenomenon, driverless cars.

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NPR Story
3:07 pm
Tue January 1, 2013

'Cliff' Deal Would End Payroll Tax Holiday

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Originally published on Tue January 8, 2013 1:19 pm

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AUDIE CORNISH, HOST:

In covering this debate, much has been made of income tax rates and where exactly they should be raised. But one fact has gotten far less notice. Starting today, payroll taxes are going up two percentage points for nearly all American workers. NPR's John Ydstie joins us to talk about it. And John, this means lower take-home pay for a lot of workers starting very soon.

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