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Becoming a rock star has major implications — just ask John Mayer. The singer-songwriter's personal history and relationships are all public knowledge, thanks to the enormous media attention that the 34-year-old attracts. The attention in turn attracts trouble, but Mayer, who has just released his fifth solo studio album, tries to take it all in stride.

Bonnie Raitt is a blues-rock legend with nine Grammys and five platinum albums under her belt. Her rootsy and passionate take on everything blues — combined with her intimate understanding of composition, deft slide-guitar skills and soulful vocals — helped Raitt become an icon.

Katie Alonzo was stunned when doctors told her they couldn't get a drug her 10-year-old daughter, Abby, was taking to fight lymphoma.

"When a doctor says, 'This is what you need to take.' And then all of a sudden somebody tells you, 'Well, that is what you need to take but this isn't available so we're going to try this instead,' it's very scary," say Alonzo, who lives in Port St. Lucie, Fla.

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ROBERT SIEGEL, HOST:

Now to a scientist looking back at the year that's about to end, commentator Adam Frank is an astrophysicist. And in the category of science, he is confident about the headline for 2012.

ADAM FRANK: Something remarkable has happened that may etch this year into history for centuries to come. Twenty-twelve's importance comes not through elections, economic shifts or the new movements in art. No, 2012 may well be remembered for something far more elemental.

This was the year that climate change got real for Americans.