But could buying a ticket in the "Show-Me" state give you a leg up?
If you believe that a state's track record of winning tickets has something to do with it, then maybe - though the odds, in fact, favor no one.
KSMU's Samuel Crowe reports that Missouri has the second-most number of Powerball winners just behind Indiana:
Susan Goedde with the Missouri Lottery Commission says she’s noticed [a] boom in ticket sales, too.
“To put it in perspective, an average week of Powerball sales in Missouri is 1.8 million [tickets]. Sales on Monday alone were 1.3 million, and Sunday and Monday together were well over 2 million,” Goedde said.
Goedde says the Missouri Lottery Commission anticipates selling 5 million tickets for this drawing. Though the odds play in nobody’s favor in the Powerball, she says Missourians might have a better shot than others around the country.
How many Missourians have won a Powerball jackpot? 26, Goedde says.
Follow Kelsey Proud on Twitter: @KelseyProud