The St. Louis landscape was Eugene Mackey’s architectural canvas; his palette was integrity, artistic genius and spirituality. “You work on a project until you find the soul of it,” his longtime friend, Van Brokaw, said he once told him. “Spirituality was an important underpinning in his life." In a career that spanned more than 50 years, Mr. Mackey infused more than 3,000 spaces with a spirit of humanity, inextricably interwoven with beauty and functionality. He died on Sunday (Nov. 27) of an aggressive form of squamous cell carcinoma (skin cancer) at Barnes-Jewish Hospital. He was 77 and had lived in Ladue.