Scott Air Force Base plans to cut more than 300 jobs as part of an Air Force restructuring plan and could get rid of more positions.
Base spokeswoman Karen Petitt said 321 jobs will be cut. Of those 122 are vacant. The base about 25 miles east of St. Louis has 5,085 civilian jobs so the cuts represent 6.3 percent of its civilian positions.
The Air Force is cutting about 9,000 jobs around the country to save money and restructure civilian operations.
Unemployment in Illinois rose in September for a fifth straight month and hit 10 percent for the first time since August 2010.
The state Department of Employment Security on Thursday blamed continued weakness in consumer confidence across the country for the increase. The federal government earlier this month said national unemployment for September was 9.1 percent. That was unchanged from August. The state rate was 9.9 percent in August.