Genome | St. Louis Public Radio


Washington University scientists are identifying genetic features of flu viruses to investigate how to predict flu pandemics.
Credit Jacco Boon and Graham Williams | Washington University St. Louis

Washington University scientists are identifying genetic features of flu viruses to investigate how to predict flu pandemics. 

In a study published in the Nature Communications journal, researchers Jacco Boon, Graham Williams, and Sebla Kutluay write that focusing on the genetic makeup of a flu virus can determine how they replicate and mutate.

Jane Ades, NHGRI

Originally published on Wednesday, February 26, 2014. Updated to include audio from St. Louis on the Air.

(Courtesy: Washington University in St. Louis)

Four of the top twenty-one influential researchers in the world live in the St. Louis area.

The researchers are from Washington University in St. Louis and all are in the field of genomics.  The findings come from Thomson Reuters ScienceWatch, an open web resource for science metrics and analysis.

Benjamin Raphael, Brown University

In separate studies both published today, researchers at Washington University mapped the genomes of two types of cancer: endometrial cancer, and acute myeloid leukemia.

Both studies are part of The Cancer Genome Atlas project, an effort funded by the National Institutes of Health to study the genetic basis of 20 major human cancers.

Jane Ades, NHGRI

An international consortium of researchers has sequenced the genomes of more than 1000 people, creating the largest catalog yet of human genetic variation.

Richard Wilson directs the Washington University Genome Institute, one of four major research institutions involved in the 1000 Genomes Project.

He says researchers identified rare genetic variants that may eventually explain why some people are more susceptible to certain diseases like cancer or Alzheimer’s.

Jane Ades, NHGRI

A federal panel is calling for stronger privacy protections for human genetic data.

In a report out today, the Presidential Commission for the Study of Bioethical Issues said “whole genome sequencing” — which provides a unique blueprint of each person’s DNA —  holds great promise for advancing medical research and clinical care.

But the Commission said genetic data can also be misused and need to be adequately protected.

There's a local connection to this development - The Genome Institute at Washington University School of Medicine says they "played an important role in this project by generating genome sequence data." Learn more via the link.

An international team of researchers has sequenced the genomes of two species of orangutan.

Lead researcher Devin Locke of the Genome Center at Washington University said a primary motivation for studying the genes of orangutans is their close evolutionary relationship to humans.

“The lessons you learn from studying these species can be applied to understanding of our own evolution and the evolution of the human population as well,” Locke said.

This article first appeared in the St. Louis Beacon: November 18, 2008 - In the world of cancer research, the patient is the unsung hero. Without patients and families willing to take part, much of genetic research into the origins of cancer would not be possible. With this partnership, scientists at Washington University in St. Louis are the first to sequence the complete genome of a tumor and compare it, side-by-side, with the genome of healthy cells from the same person. It is, they hope, a step toward personalized cancer treatment.

St. Louis can be a health and science mecca

Jul 18, 2008

This article first appeared in the St. Louis Beacon, July 18, 2008 - Anheuser-Busch has been sold; another one bites the dust.

But take a closer look and one might see some blips punctuating what many fear may be a flat-line in the landscape of our regional economy.

This article first appeared in the St. Louis Beacon: An international team of scientists has sequenced the genome of a duck-billed platypus. Part bird, part reptile and part mammal, the platypus genome sheds light on the evolution of mammals, including humans, and on the genetics of disease. Led by Richard K. Wilson, director of the Genome Sequencing Center at Washington University School of Medicine, the scientific team found that this mammal's DNA is as unusual as its duck-bill.