St. Louis Public Radio News
9:34 am
Tue December 28, 2004

Wash U. Study: Mice Might Hold Clues to Human Depression

St. Louis – Researchers at Washington University say a study of mice could offer insight into human depression.

The St. Louis researchers say engineered mice missing a specific protein from their brains react to stress differently.

The engineered mice develop an imbalance in a hormone involved in stress responses. During stressful situations, they behave as if they are depressed.

The scientists say genetic variations in the same protein may be a significant cause of human depression.

Their report is published in the upcoming Proceedings of the National Academy of Sciences.